Recent Posts

Our research about the Tumor-Associated Carbohydrate Tn Antigens spotlight in JACS

We report that two seemingly similar variants of Tn antigens have very different conformations in water. Using interdisciplinary approaches, both experimental and computational, the team showed that the threonine-linked Tn antigen assumes a rigid form in solution and forms a persistent water pocket. In contrast, the serine-linked Tn antigen lacks the water pocket and is flexible in solution. These differences were not observed in gas phase studies.
The different Tn antigen conformations are likely to result in distinct interactions with cellular receptors and antibodies and understanding these structures may facilitate the design of more effective screening tools and anticancer drugs.
The investigation has been published in JACS.

Emilio J. Cocinero gives a talk in Kaiserslautern, Germany

Emilio J. Cocinero was invited by Markus Gerhards to Kaiserslautern, Germany, where he presented several studies on biomolecules (carbohydrates and glycopeptides) and several applications, exploiting an experimental strategy which combines microwave and laser spectroscopies in high resolution, computation and synthesis. In addition, other applications of high resolution spectroscopies were presented.

Emilio J. Cocinero gives a talk in The Biofisika Institute, Bilbao

Emilio J. Cocinero attended to the Biophysics Seminar in The Biofisika Institute in Bilbao. He presented several results on the conformational landscape of several carbohydrates, peptides and glycopeptides with different biological roles, which have been obtained due to the combination of Laser and Microwave spectroscopy and theoretical calculations.

Emilio J. Cocinero gives a talk in the ICMol, Valencia

Emilio J. Cocinero gave a talk at the Instituto de Ciencia Molecular (ICMol) in Valencia about several studies on carbohydrates exploiting an experimental strategy which combines microwave and laser spectroscopies in high resolution, computation and synthesis. Carlos Martí-Gastaldo was the host.

Emilio J. Cocinero gives a talk in the IBBI 2018 in Texel, Holland

Emilio J. Cocinero was invited to the 10th edition of the Isolated Biomolecules Biomolecular Interactions “IBBI 2018”.

He presents several studies about the elucidation of biomolecule structures (carbohydrates and glycopeptides) through high resolution spectroscopies.

In the photo, IRID spectra of Tn-Thr* and Tn-Ser* Antigens presented at the talk.

Emilio J. Cocinero gives two talks in Biennial Meeting of RSEQ in Sitges

Emilio J. Cocinero was invited to give two talks in the XXXVI Biennial Meeting of the Spanish Royal Society of Chemistry in Sitges.

He particped in two different Symposiums (Structural determinants of the molecular recognition processes in biological molecules and Prebiotic chemistry in space and earth).

In the Photo, Emilio giving a talk in one of the Symposiums.

Camilla Calabrese wins competitive funding

Camilla Calabrese Camilla Calabrese has recently been awarded a Juan de La Cierva Formación Fellowship.
This is quite competitive call funded by the Spanish MINECO that highlight their excellent scientific and academic performance.
Congratulations!

Carlos Martí-Gastaldo and David González give a talk in our Department

Carlos Martí-Gastaldo gave a great talk about MOFs titled: “Charge transport and photo-activity in Metal-Organic Frameworks: Ultrathin Films and Porous Crystals” and David González about Supramolecular Chemistry: “Hierarchical Supramolecular Construction of Self-assembled Nanotubes by Coupling Cooperative Effects”.

In the photo from left to right, Carlos Martí-Gastaldo, Aurelio Mateo-Alonso, David González and Emilio J. Cocinero enjoying T-bone steak!!!

Shapes, Dynamics, and Stability of β Ionone and Its Two Mutants

We report the potential of state-of-the-art rotational technique (recently built at the University of the Basque Country) with an extended molecular analysis of three biomolecules combined to quantum chemical calculations and crystallized data comparison.

The results are impressive: more than 8000 transitions have been assigned, corresponding to the rotational structures of 54 different species (3 molecules, 14 conformers and 40 isotopologues). In addition, methyl internal rotation dynamics were also observed and analyzed.

The investigation is being published in J. Phys. Chem. Lett.

The 25th International Conference on High Resolution Molecular Spectroscopy, in Bilbao in september

The 2018 Edition of the Prague Series of International Conferences on High-Resolution Molecular Spectroscopy, to be held in Bilbao (Spain) this September 3-7.

Following the tradition of the Prague conference series, we welcome researchers from around the Globe covering all aspects and varieties of experimental studies, techniques, methods, and theory in high-resolution molecular spectroscopy.

The Bilbao 2018 Conference will be the 25th edition of the Conference, marking the ‘silver anniversary’ in its history that started biannually in 1970. Adding to a powerful scientific program with ten invited talks we will have a festive session dedicated to the anniversary of a conference that was founded to bring together spectroscopist from the East and West of Europe and all around the Globe.

Go to HRMS Conference web page

Biofisika Institute granted by Basque Government

Emilio J. Cocinero joined a new Biofisika Institute (CSIC – UPV/EHU) and it has been awarded with 3.572.296 € by 3 years by Basque Government as part of Basic Research and Excellence Centers (BERC program).

 

Our MINECO project granted

We have been awarded a 3 years project financed by MINECO that also includes a Ph. D. Scholarship to develop our research.

Gonzalo Giménez-Osses elected new president of JIQ

Emilio J. Cocinero finished his term (2014-2017) and Gonzalo Giménez Osses was elected new president of Young Chemists Division (JIQ) of the Spanish Society of Chemistry.

The meeting of Young Chemists Division was a success. In addition, Emilio gave a talk during the conference.

Prof. José Cernicharo give a seminar in our Department

Prof. José Cernicharo at Instituto de Ciencias de Materiales de Madrid (CSIC) gave a wonderful talk titled “Las moléculas y el polvo a través del ciclo de vida de las estrellas”.

He talked about his new European Project. We could also discuss about future collaborations.

Our work about Accurate Equilibrium Structures in Alkaloids cover in Chem. Eur.

This work shows the potential of semiempirical structures and how its use can be extended for the determination of accurate equilibrium structures of moderate-sized molecules. This work was a collaboration with the groups of Natalja Vogt at the University of Ulm, Alberto Lesarri at the University of Valladolid.

The cover depicts the family tree of tropane alkaloids, to which pseudopelletierine belongs, and their occurrence in nature.